ProSci

EPHB4 Recombinant Protein

Product Code:
 
PSI-96-266
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Regulatory Status:
 
RUO
Target Species:
 
Human
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Western Blot (WB)
Storage:
 
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
 

No additional charges, what you see is what you pay! *

CodeSizePrice
PSI-96-266-0.2mg0.2mg£657.00
Quantity:
Prices exclude any Taxes / VAT
How to order with us   Contact us
Stay in control of your spending. These prices have no additional charges, not even shipping!
* Rare exceptions are clearly labelled (only 0.14% of items!).
Multibuy discounts available! Contact us to find what you can save.
This product comes from: United States.
Typical lead time: 14-21 working days.
Contact us for more accurate information.
  • Further Information
  • Documents
  • Show All

Further Information

Additional Names:
EphB4, HTK, MYK1, TYRO11
Application Note:
This recombinant protein can be used for WB. For research use only.
Background:
Ephrin type-B receptor 4(EPHB4) is also known as HTK, MYK1 and TYRO11,is a member of Eph family. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by EPHB4 binds to Ephrin-B2 and plays an essential role in vascular development. EPHB4 and its ligand ephrin-B2 are specifically expressed on venous and arterial endothelial cells, respectively, and play an essential role in vascular development via bidirectional signals. The forward EPHB4 signaling inhibits cell adhesion, chemotaxis, angiogenesis and tumor growth. Incontrast, the reverse Ephrin-B2 signaling exerts the opposite effect. It has been reported that aberrant expression of EPHB4 is associated with prostate cancer and highly malignant breast cancers, accordingly, EPHB4 has potential application as a therapeutic candidate.
Background References:
  • Bennett, B.D. et al., 1994, J. Biol. Chem. 269: 14211-14218.
  • Noren, N.K. et al., 2006, Nat. Cell. Biol. 8: 815-825.
  • Xia, G. et al., 2005, Cancer Res. 65: 4623-4632.
  • Kertesz, N. et al., 2006, Blood. 107: 2330-2338.
Biological Activity:
Measured by its binding ability in a functional ELISA. Immobilized rhEPHB4 at 2μg/ml (100μl/well) can bind human EphrinB2 with a linear range of 0. 8 - 85 ng/mL.
Buffer:
PBS, pH7.4
Fusion Tag:
His Tag
NCBI Gene ID #:
2050
NCBI Official Name:
EPH receptor B4
NCBI Official Symbol:
EPHB4
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
57.8 kDa
Protein Accession #:
NP_004435.3
Purity:
>97% as determined by SDS-PAGE.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
HEK293 cells
Swissprot #:
P54760

Documents