ProSci

GFRA 1 Recombinant Protein

Product Code:
 
PSI-96-344
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Regulatory Status:
 
RUO
Target Species:
 
Human
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Western Blot (WB)
Storage:
 
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
 

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PSI-96-344-0.1mg0.1mg£657.00
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Further Information

Additional Names:
GFRA1, GDNFRA, RETL1, TRNR1, GDNFR, GFR-ALPHA-1, RET1L
Application Note:
This recombinant protein can be used for WB. For research use only.
Background:
GDNF family receptor alpha-1 (GFRA1) is also known as RET ligand 1 (RETL1), TGF-beta-related neurotrophic factor receptor 1 (TRNR1), is a novel glycosylphosphatidylinositol (GPI)-linked cell surface receptor, and belongs to the glial cell line-derived neurotrophic factor (GDNF) receptor subfamily. The GDNF family ligands comprises GDNF, Neurturin (NTN), Artemin, and Persephin. GDNF and NTN are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. GFRA1 mediates the association with and activation of the RET tyrosine kinase receptor (RTK), and subsequently initiates the RET signaling pathway. GFR alpha-mediated signaling plays an important role in the survival, differentiation, and migration of central and peripheral neurons, and is essential for the development of kidneys and the enteric nervous system, as well as the inflammatory response in some carciniomas.
Background References:
  • Angrist M, et al., 1998, Genomics 48 (3): 354?62.
  • Jing, S., et al., 1997, J. Biol. Chem. (UNITED STATES) 272 (52): 33111?7.
  • Cik, M., et al., 2000, J. Biol. Chem. (UNITED STATES) 275 (36): 27505?12.
  • Klein, R D., et al., 1997, Nature (ENGLAND) 387 (6634): 717?21.
Biological Activity:
Measured by its binding ability in a functional ELISA. Immobilized Recombinant Human GDNF at 1 μg/mL binds rhGFRA1 with an apparent KD <10 nM.
Buffer:
PBS, pH7.4
Fusion Tag:
His Tag
NCBI Gene ID #:
2674
NCBI Official Name:
GDNF family receptor alpha 1
NCBI Official Symbol:
GFRA1
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
45.5 kDa
Protein Accession #:
NP_665736.1
Purity:
>95% as determined by SDS-PAGE.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
HEK293 cells
Swissprot #:
P56159

Documents