ProSci

PLAU Recombinant Protein

Product Code:
 
PSI-96-630
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Regulatory Status:
 
RUO
Target Species:
 
Human
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Western Blot (WB)
Storage:
 
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
 

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PSI-96-630-0.05mg0.05mg£686.00
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Further Information

Additional Names:
Urokinase, PLAU, ATF, UPA, URK, u-PA, BDPLT5, QPD
Application Note:
This recombinant protein can be used for WB. For research use only.
Background:
Urokinase - type plasminogen activator is also known as PLAU and UPA, a serine protease with an extremely limited substrate specificity, cleaving the sequence Cys ? Pro ? Gly - Arg560 - Val561 ? Val ? Gly ? Gly ? Cys in plasminogen to form plasmin. uPA is a potent marker of invasion and metastasis in a variety of human cancers associated with breast, stomach, colon, bladder, ovary, brain and endometrium.uPA and its receptor (uPAR) have been implicated in a broad spectrum of pathophysiological processes, including fibrinolysis, proteolysis, inflammation, atherogenesis and plaque destabilization, all of which are involved in the pathogenesis of MI (myocardial infarction).
Background References:
  • Nagai M., et al., 1985, Gene 36:183.
  • Jacobs P., et al., 1985, DNA 4:139.
  • Harbeck, N. et al., 2002, Clin. Breast Cancer 3:196.
Biological Activity:
Measured by its ability to bind human PLAUR in a function ELISA.
Buffer:
50 mM NaAc, 100 mM NaCl, pH5.0
Fusion Tag:
His Tag
NCBI Gene ID #:
5328
NCBI Official Name:
plasminogen activator, urokinase
NCBI Official Symbol:
PLAU
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
45 kDa
Protein Accession #:
NP_002649.1
Purity:
>95% as determined by SDS-PAGE.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
HEK293 cells
Swissprot #:
P00749

Documents