ProSci

Semaphorin 4A Recombinant Protein

Product Code:
 
PSI-96-686
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Regulatory Status:
 
RUO
Target Species:
 
Human
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Western Blot (WB)
Storage:
 
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
 

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PSI-96-686-0.1mg0.1mg£626.00
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Further Information

Additional Names:
SEMA4A, SEMAB, SEMB, Semaphorin-4A, Semaphorin-B
Application Note:
This recombinant protein can be used for WB. For research use only.
Background:
Semaphorin-4A (SEMA4A) is also known as Semaphorin-B (SEMAB), which belongs to the semaphorin family. SEMA4A contains one Ig-like C2-type (immunoglobulin-like) domain, one PSI domain and one sema domain. SEMA4A is cell surface receptor for PLXNB1, PLXNB2, PLXNB3 and PLXND1 that plays an important role in cell-cell signaling. SEMA4A plays a role in priming antigen-specific T-cells, promotes differentiation of Th1 T-helper cells, and thereby contributes to adaptive immunity. SEMA4A also promotes phosphorylation of TIMD2 and inhibits angiogenesis. SEMA4A promotes axon growth cone collapse and inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons.
Background References:
  • Abid A., et al., 2006, J. Med. Genet. 43:378-381.
Biological Activity:
Measured by its ability to bind biotinylated mouse SEMA4D in a functional ELISA.
Buffer:
PBS, pH7.4
Fusion Tag:
His Tag
NCBI Gene ID #:
64218
NCBI Official Name:
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
NCBI Official Symbol:
SEMA4A
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
72.7 kDa
Protein Accession #:
AAH20974
Purity:
>95% as determined by SDS-PAGE.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
HEK293 cells
Swissprot #:
Q9H3S1

Documents