ProSci

Osteoprotegerin Recombinant Protein

Product Code:
 
PSI-96-739
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Regulatory Status:
 
RUO
Target Species:
 
Human
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Western Blot (WB)
Storage:
 
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
 

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PSI-96-739-0.1mg0.1mg£481.00
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Further Information

Additional Names:
TNFRSF11B, OCIF, OPG, Osteoprotegerin
Application Note:
This recombinant protein can be used for WB. For research use only.
Background:
Tumor necrosis factor receptor superfamily member 11B (TNFRSF11B) is also known as Osteoclastogenesis inhibitory factor (OCIF), Osteoprotegerin (OPG). TNFRSF11B is a secreted homodimer protein, which can interact with TNFSF10 and TNFSF11. TNFRSF11B acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. TNFRSF11B inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis.
Background References:
  • Tsuda E., et al, 1997, Biochem. Biophys. Res. Commun. 234:137-142.
  • Emery J.G., et al., 1998, J. Biol. Chem. 273:14363-14367.
  • Luan X., et al., 2012, J. Immunol. 189:245-252.
Biological Activity:
Measured by its binding ability in a functional ELISA. Immobilized rh TNFRSF11B at 10μg/ml (100μl/well) can bind human TNFSF11 Fc Chimera with a linear ranger of 4-256 ng/mL.
Buffer:
PBS, pH7.4
Fusion Tag:
His Tag
NCBI Gene ID #:
4982
NCBI Official Name:
tumor necrosis factor receptor superfamily, member 11b
NCBI Official Symbol:
TNFRSF11B
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
44.4 kDa
Protein Accession #:
NP_002537
Purity:
>95% as determined by SDS-PAGE.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
HEK293 cells
Swissprot #:
O00300

Documents