ProSci

ALK 1 Recombinant Protein

Product Code:
 
PSI-96-022
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Western Blot (WB)
Storage:
 
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
 

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PSI-96-022-0.1mg0.1mg£626.00
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Further Information

Additional Names:
ACVRL1, ACVRLK1, ALK-1, HHT, HHT2, ORW2, SKR3, TSR-I
Application Note:
This recombinant protein can be used for WB. For research use only.
Background:
Serine/threonine-protein kinase receptor R3 is an enzyme that in humans is encoded by the ALK1 gene. ALK1 is a receptor in the TGF beta signaling pathway. ALK1 protein is a receptor in the TGF beta signaling pathway. It plays an important role in vascular development, remodeling, and pathologic angiogenesis, play a role in stabilizing angiogenic vessels and contribute to resistance to anti-VEGF therapies, ALK1 blockade may represent an effective therapeutic opportunity complementary to the current antiangiogenic modalities in the clinic. Recently, researcher found that, ALK1-Fc inhibited BMP9-mediated Id-1 expression in human umbilical vein endothelial cells and inhibited cord formation by these cells on a Matrigel substrate, in a chick chorioallantoic membrane assay, ALK1-Fc reduced vascular endothelial growth factor-, fibroblast growth factor-, and BMP10-mediated vessel formation, and ALK1-Fc treatment reduced tumor burden in mice receiving orthotopic grafts of MCF7 mammary adenocarcinoma cells.
Background References:
  • Ten Dijke P, Ichijo H, et al.,1993, Oncogene 8 (10): 2879?87.
  • Johnson DW, Berg JN, et al., 1996, Nat Genet 13 (2): 189?95.
  • Lawlor MW, Read BP, et al., 2011, Am J Pathol. 178(2):784-93.
  • Mitchell D,et al., 2010, Mol Cancer Ther.. 9(2):379-88.
Buffer:
PBS, pH7.4
Fusion Tag:
His Tag
NCBI Gene ID #:
94
NCBI Official Name:
activin A receptor type II-like 1
NCBI Official Symbol:
ACVRL1
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
12.3 kDa
Protein Accession #:
NP_000011.2
Purity:
>97% as determined by SDS-PAGE.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
HEK293 cells
Swissprot #:
P37023

Documents