ProSci

SERPINA3 Recombinant Protein

Product Code:
 
PSI-96-684
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Western Blot (WB)
Storage:
 
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
 

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PSI-96-684-0.05mg0.05mg£686.00
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Further Information

Additional Names:
SERPINA3, ACT, AACT, GIG24, GIG25
Application Note:
This recombinant protein can be used for WB. For research use only.
Background:
Serpin A3 is also known as Alpha-1-antichymotrypsin (ACT or AACT), Cell growth-inhibiting gene 24/25 protein, which belongs to the serpin family. Serpin A3 can bind DNA. Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2.
Background References:
  • Rubin H., et al., 1990, J. Biol. Chem. 265:1199-1207.
  • Kroczynska B., et al., 2004, J. Biol. Chem. 279:11432-11443.
  • Liu T., et al., 2005, J. Proteome Res. 4:2070-2080.
Biological Activity:
Measured by its ability to inhibit chymotrypsin cleavage of a fluorogenic peptide substrate MCA-RPKPVE-Nval-WRK(Dnp)-NH2. The IC50 value is <6 nM.
Buffer:
20 mM HEPES, 150 mM NaCl, pH 7.5
Fusion Tag:
His Tag
NCBI Gene ID #:
12
NCBI Official Name:
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
NCBI Official Symbol:
SERPINA3
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
46 kDa
Protein Accession #:
AAH03559
Purity:
>95% as determined by SDS-PAGE.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
HEK293 cells
Swissprot #:
P01011

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