ProSci

Interferon gamma Recombinant Protein (HEK293 Expressed)

Product Code:
 
PSI-96-409
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Western Blot (WB)
Storage:
 
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
 

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PSI-96-409-0.1mg0.1mg£452.00
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Further Information

Additional Names:
IFNG, IFG, IFI
Application Note:
This recombinant protein can be used for WB. For research use only.
Background:
Interferon-gamma (IFN-γ/IFNG) is a dimerized soluble cytokine that is the only member of the type II class of interferon. This interferon was originally called macrophage-activating factor, a term now used to describe a larger family of proteins to which IFN-γ belongs. IFN-gamma has been used in a wide variety of clinical indications. Interferon-gamma (IFNgamma) is a central regulator of the immune response and signals via the Janus Activated Kinase (JAK)-Signal Transducer and Activator of Transcription (STAT) pathway. Interferon gamma has broader roles in activation of innate and adaptive immune responses to viruses and tumors, in part through upregulating transcription of genes involved in cell cycle regulation, apoptosis, and antigen processing/presentation. Despite this, rodent and human trophoblast cells show dampened responses to IFNG that reflect the resistance of these cells to IFNG-mediated activation of major histocompatibility complex (MHC) class II transplantation antigen expression.
Background References:
  • Gray PW, et al., 1982, Nature 298 (5877): 859?63.
  • Miller CH, et al., 2009, Ann N Y Acad Sci.1182:69-79.
  • Saha B, et al., 2010, Cytokine. 50(1):1-14.
  • Murphy SP, et al., 2009, Biol Reprod. 80(5):848-59.
Biological Activity:
The bio-activity of IFN-gamma was determined by dose-dependent inhibition of the proliferation of HT-29 cells. The EC50 for this effect is typically 0.41-0.74 ng/mL.
Buffer:
PBS, pH7.4
Fusion Tag:
Tag free
NCBI Gene ID #:
3458
NCBI Official Name:
interferon, gamma
NCBI Official Symbol:
IFNG
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
16.8 kDa
Protein Accession #:
AAH70256
Purity:
>90% as determined by SDS-PAGE.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
HEK293 cells
Swissprot #:
P01579

Documents