ProSci

EpCAM Recombinant Protein

Product Code:
 
PSI-96-276
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Regulatory Status:
 
RUO
Target Species:
 
Mouse
Application:
 
Western Blot (WB)
Storage:
 
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
 

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PSI-96-276-0.1mg0.1mg£626.00
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Further Information

Additional Names:
EPCAM, TACSTD1, TROP1, CD326, DIAR5, EGP2, EGP314, EGP40, ESA, GA733-2, HNPCC8, HNPCC-8, KS1/4, KSA, M4S1, MIC18, MK1
Application Note:
This recombinant protein can be used for WB. For research use only.
Background:
EpCAM is also known as CO171A, EGP, EGP40, GA7332, KSA, M4S, MIC18, MK1, TROP1, hEGP2, and is a pan-epithelial differentiation antigen that is expressed on almost all carcinomas as 17-1A(mAb) antigen. Its constitutional function is being elucidated. It is intricately linked with the Cadherin-Catenin pathway and hence the fundamental WNT pathway responsible for intracellular signaling and polarity. The epithelial cell adhesion molecule (Ep-CAM) is known to express in most epithelial malignancies and was reported as a tumor marker or a candidate of molecular targeting therapy. Ep-CAM cross signaling with N-cadherin involves Pi3K, resulting in the abrogation of the cadherin adhesion complexes in epithelial cells was reported. And Epithelial cell adhesion molecule (Ep-CAM) recently received increased attention as a prognostic factor in breast cancer.
Background References:
  • Linnenbach, et al., 1993, Mol Cell Biol 13 (3): 1507?15.
  • Akita H, et al., 2011, Oncogene.
  • Winter MJ, et al., 2007, Mol Cell Biochem. 302(1-2):19-26.
  • Schmidt M, et al., 2011, Breast Cancer Res Treat. 125(3):637-46.
Buffer:
PBS, pH7.4
Fusion Tag:
His Tag
NCBI Gene ID #:
17075
NCBI Official Name:
epithelial cell adhesion molecule
NCBI Official Symbol:
Epcam
NCBI Organism:
Mus musculus
Physical State:
Lyophilized
Predicted Molecular Weight:
28.5 kDa
Protein Accession #:
AAH05618.1
Purity:
>98% as determined by SDS-PAGE.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
HEK293 cells
Swissprot #:
Q99JW5

Documents