ProSci

Cardif Antibody [Adri-1]

Product Code:
 
PSI-36-098
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Mouse
Antibody Isotype:
 
IgG2b
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
Adri-1
Regulatory Status:
 
RUO
Target Species:
 
Human
Applications:
  • Immunocytochemistry (ICC)
  • Immunohistochemistry (IHC)
  • Immunoprecipitation (IP)
  • Western Blot (WB)
Storage:
 
Stable for at least 1 year after receipt when stored at -20˚C.
 

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PSI-36-098-100ug100ug£686.00
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Further Information

Additional Names:
CARD Adapter Inducing Interferon-beta; IPS-1; MAVS; Mitochondrial Antiviral Signaling Protein; VISA; Virus-induced Signaling Adapter; Interferon-beta Promoter Stimulator Protein 1
Application Note:
Immunocytochemistry: (1:100). Immunohistochemistry: (paraffin sections). Immunoprecipitation: (1:200). Western Blot: (1:1,000).
Background:
RIG-I (retinoic acid-inducible gene I; Ddx58) and MDA5 (melanoma differentiation-associated gene 5, also known as Ifih1 or Helicard) are proteins that sense viral replication intermediates, such as double-stranded RNA and triggers the host antiviral programs. These molecules signal the downstream activation of NF-kappaB and IFN regulatory factor (IRF) -3, which coordinately regulate the expression of type-I interferons. Cardif (also called VISA/IPS-1/MAVS) is a new CARD (caspase activation and recruitment domain)-containing adaptor protein that interacts with the CARD domain of RIG-I and MDA5, leading to the activation of NF-kappaB and IRF3. Cardif is located to the mitochondrial outer membrane. Removal of the mitochondrial-targeting domain of cardif abolishes its ability to induce IFNs. Cardif is cleaved and inactivated by NS3-4A, a serine protease from hepatitis C virus known to block interferon-beta production.
Buffer:
Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.
Concentration:
1 mg/ml
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Recombinant human Cardif (aa 160-450).
NCBI Gene ID #:
57506
NCBI Official Name:
mitochondrial antiviral signaling protein
NCBI Official Symbol:
MAVS
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
83776598
Protein GI Number:
NP_065797
Purification:
>95% (SDS-PAGE)
Research Area:
Immunology,Innate Immunity
SPECIFICITY:
Recognizes human Cardif.
Swissprot #:
Q7Z434
User NOte:
Optimal dilutions for each application to be determined by the researcher.