ProSci

GPx8 Antibody

Product Code:
 
PSI-36-337
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Human
Applications:
  • Immunocytochemistry (ICC)
  • Western Blot (WB)
Storage:
 
Stable for at least 1 year after receipt when stored at -20˚C.
 

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PSI-36-337-100ug100ug£686.00
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Further Information

Additional Names:
Probable Glutathione Peroxidase 8; GSHPx-8
Application Note:
Western Blot: (1:1,000). ICC: (1:200).
Background:
GPxs are glutathione peroxidases involved in balancing the H2O2 homeostasis in signaling cascades. GPxs have been known to catalyze the reduction of H2O2 or organic hydroperoxides to water or the corresponding alcohols, respectively, typically using glutathione (GSH) as reductant. GPx8 (probable glutathione peroxidase 8) is a 209-aa, 24kDa protein with an N-terminal cytosolic tip, a predicted transmembrane segment and a catalytic domain located in the endoplasmic reticulum (ER) lumen. GPx8 is a CysGPxs with low glutathione peroxidase activity. A recent study identified GPx8 as a cellular substrate of the hepatitis C virus NS3-4A protease. GPx8 cleavage by NS3-4A occurs at Cys11, removing the cytosolic tip of GPx8 and was observed in different experimental systems as well as in liver biopsies from patients with chronic hepatitis C.
Buffer:
Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.
Concentration:
1 mg/ml
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Recombinant GPx8 (human) (aa 38-209) fused to a GST-tag.
NCBI Gene ID #:
493869
NCBI Official Name:
glutathione peroxidase 8 (putative)
NCBI Official Symbol:
GPX8
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
269849565
Protein GI Number:
Q8TED1
Research Area:
Immunology,Innate Immunity
SPECIFICITY:
Recognizes human GPx8.
Swissprot #:
Q8TED1
User NOte:
Optimal dilutions for each application to be determined by the researcher.