ProSci

TIP60 highly active Recombinant Protein

Product Code:
 
PSI-90-347
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Regulatory Status:
 
RUO
Target Species:
 
Human
Shipping:
 
Dry ice
Storage:
 
Stable for at least 6 months after receipt when stored at -80˚C.
 

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PSI-90-347-2ug2ug£522.00
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Further Information

Additional Names:
Histone Acetyltransferase HTATIP, Histone Acetyltransferase KAT5, Lysine Acetyltransferase 5, 60 kDa Tat-interactive Protein
Application Note:
This recombinant proteins is for research use only.
Background:
TIP60 is the catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex is required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. TIP60 directly acetylates and activates ataxia-telangiectasia mutated (ATM). In case of HIV-1 infection, interaction with the viral Tat protein leads to KAT5 polyubiquitination and targets it to degradation.
Biological Activity:
100-200ng are required for standard HAT assay.
Buffer:
In 50mM TRIS-HCl, pH 7.5, containing 100mM sodium chloride, 0.2% NP-40, 50mM imidazole and 10% glycerol.
Concentration:
Lot dependent (0.2-0.5mg/ml)
Fusion Tag:
His Tag
NCBI Gene ID #:
10524
NCBI Official Name:
K(lysine) acetyltransferase 5
NCBI Official Symbol:
KAT5
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
Q92993
Protein GI Number:
36287069
Purity:
>95% (SDS-PAGE)
Recombinant Protein Sequence:
Thr32-Gly402
Source:
Sf21 cells
Swissprot #:
O00175

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