ProSci

CD275 [B7-H2] Recombinant Protein

Product Code:
 
PSI-90-435
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Regulatory Status:
 
RUO
Target Species:
 
Human
Storage:
 
Stable for at least 1 year after receipt when stored at -20˚C. Working aliquots are stable for up to 3 months when stored at -20˚C.
 

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PSI-90-435-100ug100ug£657.00
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Further Information

Additional Names:
B7-H2, ICOS Ligand, B7-like Protein Gl50, B7RP-1
Application Note:
This recombinant proteins is for research use only.
Background:
Human B7-H2 is a member of the growing B7 family of immune costimulatory proteins. Other family members include B7-1, B7-2, B7-H1 (PD-L1), PD-L2 and B7-H3. B7 proteins are members of the immunoglobulin (Ig) superfamily, the extracellular domains contain 2 Ig-like domains and all members have short cytoplasmic domains. B7-H2 has been identified as the ligand for ICOS, a member of the CD28 family of costimulatory receptors. Human B7-H2 is expressed constitutively on resting B cells, dendritic cells and at low levels on monocytes. The B7-H2/ICOS interaction appears to play roles in T cell dependent B cell activation and Th differentiation.
Biological Activity:
Measured by its ability to stimulate human T cell proliferation in the presence of anti-CD3.
Buffer:
Lyophilized from 0.2um-filtered solution in PBS. Reconstitute with 100 μl sterile water. Add 1X PBS to the desired protein concentration.
Fusion Tag:
Fc Tag
NCBI Gene ID #:
23308
NCBI Official Name:
inducible T-cell co-stimulator ligand
NCBI Official Symbol:
ICOSLG
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Protein Accession #:
NP_056074
Protein GI Number:
27477039
Purity:
>98% (SDS-PAGE).

Endotoxin level is less than 0.06EU/ μg protein (LAL test; Lonza).
Recombinant Protein Sequence:
Thr32-Gly402
Source:
CHO cells
Swissprot #:
P05231

Documents