IL-1alpha Recombinant Protein

Interleukin-1alpha, IL-1F1, IL-1A

This recombinant proteins is for research use only.

The most prominent members of the interleukin-1 (IL-1) superfamily are IL-1alpha and IL-1beta. They lack a signal peptide and are secreted by an unconventional, endoplasmic reticulum-Golgi-independent mechanism. IL-1alpha was reported to be more widely and constitutively expressed and has intracellular functions, but also acts locally in a membrane-bound form by activating IL-1R1. Additionally, passive release of IL-1alpha upon cell death can trigger a sterile inflammatory response to dying cells. The cleavage of IL-1alpha is not mediated by caspase-1 and is not required for binding to IL-1R1. Recently it has been observed that all activators of the inflammasome NLRP3/NALP3 induce the simultaneous secretion of IL-1alpha and IL-1beta. Although most activators fully rely on the inflammasome for IL-1alpha secretion, some induce the processing and secretion of IL-1alpha in an inflammasome-independent manner.

Lyophilized from a concentrated sterile solution containing 50mM Tris-HCl buffer (pH 8.0) and 100mM NaCl. Reconstituted in sterile H2O not less than 100 μg/ml, which can then be further diluted in other aqueous solutions.

His Tag

3552

interleukin 1 alpha?

IL1A

Homo sapiens

Lyophilized

NP_000566

27894330

>98% (SDS-PAGE).

Endotoxin level is less than 0.1EU/ μg protein (LAL test; Lonza).

Thr32-Gly402

E. coli

Q9HBE4