Complement factor H Recombinant Protein

Complement factor H, CFH

This recombinant protein can be used for biological assays. For research use only.

Complement Factor H (CFH) is a secreted protein which is a member of the regulators of complement activation family and is a complement control protein. It is expressed by the liver and secreted in plasma. Its principal function is to regulate the Alternative Pathway of the complement system, ensuring that the complement system is directed towards pathogens or other dangerous material and does not damage host tissue. Factor H regulates complement activation on self cells and surfaces by possessing both cofactor activity for the Factor I mediated C3b cleavage, and decay accelerating activity against the alternative pathway C3-convertase, C3bBb. Factor H exerts its protective action on self cells and self surfaces but not on the surfaces of bacteria or viruses, because it binds to glycosaminoglycans (GAGs) that are generally present on host cells but not, normally, on pathogen surfaces.

Supplied as a 0.2 um filtered solution of PBS,20%Glycerol,5% Trehalose,pH7.4. It is not recommended to reconstitute to a concentration less than 100 ug/ml.

C-6 His tag

3075

complement factor H

CFH

Homo sapiens

Liquid

50 kD

P08603-2

Greater than 95% as determined by reducing SDS-PAGE.
Endotoxin level less than 0.1 ng/ug (1 IEU/ug) as determined by LAL test.

Thr32-Gly402

Human Cells

P08603-2