ProSci

IL-36Ra Recombinant Protein

Product Code:
 
PSI-90-280
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Regulatory Status:
 
RUO
Target Species:
 
Mouse
Storage:
 
Stable for at least 6 months after receipt when stored at -20˚C.
 

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PSI-90-280-10ug10ug£433.00
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Further Information

Additional Names:
Interleukin-36 Receptor Antagonist Protein, IL-1F5, Interleukin-1 Family Member 5, IL-1delta, Interleukin-1delta, Interleukin-1 Homolog 3, Interleukin-1-like Protein 1
Application Note:
This recombinant proteins is for research use only.
Background:
IL-36Ra/IL-1F5 is a highly and a specific antagonist of the IL-1 receptor-related protein 2-mediated response to IL-36alpha (IL-1F6), IL-36beta (IL-1F8) and IL-36gamma (IL-1F9). These cytokines bind to IL-36R (IL-1Rrp2) and IL-1RAcP, activating similar intracellular signals as IL-1. IL-36Ra inhibits the production of proinflammatory cytokines, including IL-12, IL-1beta, IL-6, TNF-alpha and IL-23 induced by IL-36 in BMDC and CD4 T cells. Skin and dendritic cells are target of the IL-36 interleukins leading to a Th1 response. Recently mutations that affect the levels and the activity of IL-36Ra have been found in patients with pustular psoriasis, leading to enhanced production of inflammatory cytokines (IL-8 in particular) by keratinocytes.
Biological Activity:
Inhibits the IL-6 induced expression of IL-36alpha (IL-1F6), IL-36beta (IL-1F8), and IL-36gamma (IL-1F9) in BMDCs. 1ug/ml of IL-36Ra inhibits the activity of 10 ng to 100 ng/ml of the agonists.
Buffer:
Contains PBS. Reconstitute with 100 μl sterile water.
Concentration:
0.1mg/ml after reconstitution.
Fusion Tag:
Tag Free
NCBI Gene ID #:
54450
NCBI Official Name:
interleukin 1 family, member 5 (delta)
NCBI Official Symbol:
Il1f5
NCBI Organism:
Mus musculus
Physical State:
Lyophilized
Protein Accession #:
Q9QYY1
Protein GI Number:
25008597
Purity:
>95% (SDS-PAGE).

Endotoxin level is less than 0.05EU/ μg purified protein (LAL test; Lonza).
Recombinant Protein Sequence:
Thr32-Gly402
Source:
E. coli
Swissprot #:
Q9Y275

Documents