ProSci

CD275 [B7-H2] non-lytic Recombinant Protein

Product Code:
 
PSI-90-437
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Regulatory Status:
 
RUO
Target Species:
 
Mouse
Storage:
 
Stable for at least 1 year after receipt when stored at -20˚C. Working aliquots are stable for up to 3 months when stored at -20˚C.
 

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PSI-90-437-100ug100ug£657.00
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Further Information

Additional Names:
B7-H2, ICOS Ligand, B7-like Protein Gl50, B7RP-1
Application Note:
This recombinant proteins is for research use only.
Background:
Mouse CD275 (B7-H2) is a member of the growing B7 family of immune costimulatory proteins. CD275 has been identified as the ligand for ICOS, a member of the CD28 family of co-stimulatory receptors. Mouse CD275 is expressed on resting B cells and at low levels on monocytes. The CD275/ICOS interaction appears to play roles in T cell dependent B cell activation and Th differentiation.
Biological Activity:
Measured by its binding ability in a functional ELISA. Immobilized human ICOS at 1ug/ml (100ul/well) can bind biotinylated B7-H2 (mouse):Fc (mouse) (rec.) (non-lytic) with a linear range of 0.1-1.0ug/ml. Optimal dilutions should be determined by each laboratory for each application.
Buffer:
Lyophilized from 0.2um-filtered solution in PBS. Reconstitute at 100 μg/ml in sterile PBS.
Fusion Tag:
Fc Tag
NCBI Gene ID #:
50723
NCBI Official Name:
icos ligand
NCBI Official Symbol:
Icosl
NCBI Organism:
Mus musculus
Physical State:
Lyophilized
Protein Accession #:
NP_056605
Protein GI Number:
7657220
Purity:
>98% (SDS-PAGE).

Endotoxin level is less than 0.06EU/ μg protein (LAL test; Lonza).
Recombinant Protein Sequence:
Thr32-Gly402
Source:
CHO cells
Swissprot #:
P05231

Documents