ProSci

Legumain Recombinant Protein

Product Code:
 
PSI-92-481
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Regulatory Status:
 
RUO
Target Species:
 
Mouse
Storage:
 
Lyophilized protein should be stored at -20˚C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7˚C for 2-7 days.
Aliquots of reconstituted samples are stable at -20˚C for 3 months.
 

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PSI-92-481-0.05mg0.05mg£838.00
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Further Information

Additional Names:
Legumain, Lgmn, Asparaginyl endopeptidase, Protease cysteine 1, Prsc1
Application Note:
This recombinant protein can be used for biological assays. For research use only.
Background:
Mouse Legumain,also known as LGMN, is a cysteine protease belonging to peptidase family C13 and is expressed in kidney and placenta abundantly. LGMN has a strict specificity for hydrolysis of asparaginyl bonds. It can also cleave aspartyl bonds slowly, especially under acidic conditions. The mammalian legumain is involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system. It plays a role in the regulation of cell proliferation via its role in EGFR degradation. Legumain deficiency causes the accumulation of pro-Cathepsins B, H and L, another group of lysosomal cysteine proteases. Overexpression of Legumain in tumors is significant for invasion/metastasis. Mammalian legumain is inhibited by iodoacetamide and maleimides. Legumain activation appears to be autocatalytic and can be triggered by acidic pH.
Buffer:
Supplied as 0.2 um filtered solution of 20mM Tris,150mM NaCl,pH 8.0.
Fusion Tag:
C-6 His tag
NCBI Gene ID #:
19141
NCBI Official Name:
legumain
NCBI Official Symbol:
Lgmn
NCBI Organism:
Mus musculus
Physical State:
Liquid
Predicted Molecular Weight:
48.7 kD
Protein Accession #:
O89017
Purity:
Greater than 95% as determined by reducing SDS-PAGE.
Endotoxin level less than 0.1 ng/ug (1 IEU/ug) as determined by LAL test.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
Human Cells
Swissprot #:
O89017

Documents