Further Information
Granulocyte-Macrophage Colony-Stimulating Factor, GM-CSF, Colony-Stimulating Factor, CSF, Molgramostin, Sargramostim, CSF2, GMCSF
This recombinant protein can be used for biological assays. For research use only.
GM-CSF was initially characterized as a growth factor that can support the in vitro colony formation of granulocyte macrophage progenitors. It is produced by a number of different cell types (including activated T cells, B cells, macrophages, mast cells, endothelial cells and fibroblasts) in response to cytokine of immune and inflammatory stimuli. Besides granulocyte-macrophage progenitors, GM-CSF is also a growth factor for erythroid, megakaryocyte and eosinophil progenitors. On mature hematopoietic, monocytes/macrophages, and eosinophils, GM-CSF has also been reported to have a functional role on non-hematopoitic cells. It can induce human endothelial cells to migrate and proliferate. Additionally, GM-CSF can also stimulate the proliferation of a number of tumor cell lines, including osteogenic sarcoma, carcinoma and adenocarcinoma cell lines.
ED50 is less than 0.2 ng/ml as determined by the dose-dependent stimulation of the proliferation of human TF-1 cells.
Specific Activity of 5.0 x 106 IU/ mg.
Lyophilized from a 0.2 um filtered solution of 10mM TrisHCl, 4% Mannitol, 1% Sucrose, pH 8.5. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O.
Tag Free
1437
colony stimulating factor 2
CSF2
Homo sapiens
Lyophilized
Predicted Molecular Weight:
14.4 kD
P04141
767957252
Greater than 95% as determined by reducing SDS-PAGE.
Endotoxin level less than 0.1 ng/ug (1 IEU/ug) as determined by LAL test.
Recombinant Protein Sequence:
Thr32-Gly402
P. pastoris
P04141
