SLP-76 Recombinant Protein

Lymphocyte cytosolic protein 2, SH2 domain-containing leukocyte protein of 76 kDa, SLP-76 tyrosine phosphoprotein, SLP76, LCP2

This recombinant protein can be used for biological assays. For research use only.

Lymphocyte cytosolic protein 2 (LCP2) contains a SAM domain and a SH2 domain. It is highly expressed in spleen, thymus and peripheral blood leukocytes, T-cell and monocytic cell lines, but expressed at lower level in B-cell lines. LCP2 was originally identified as a substrate of the ZAP-70 protein tyrosine kinase following T cell receptor (TCR) ligation in the leukemic T cell line Jurkat. It is phosphorylated after T-cell receptor activation by ZAP70, ITK and TXK, which leads to the up-regulation of Th1 preferred cytokine IL-2 during post-translational modification. Studies using LCP2-deficient T cell lines or mice have provided strong evidence that SLP-76 plays a positive role in promoting T cell development and activation as well as mast cell and platelet function.

Supplied as a 0.2 um filtered solution of 20mM Tris,150mM NaCl,20% glycerol, pH 8.5. It is not recommended to reconstitute to a concentration less than 100 ug/ml.

C-6 His, N-T7 tag

3937

lymphocyte cytosolic protein 2

LCP2

Homo sapiens

Liquid

62.6 kD

Q13094

767904139

Greater than 95% as determined by reducing SDS-PAGE.
Endotoxin level less than 0.1 ng/ug (1 IEU/ug) as determined by LAL test.

Thr32-Gly402

E. coli

Q13094