ProSci

Peroxiredoxin-1 Recombinant Protein

Product Code:
 
PSI-92-274
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Regulatory Status:
 
RUO
Target Species:
 
Human
Storage:
 
Store at -20˚C, stable for 6 months after receipt.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
 

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CodeSizePrice
PSI-92-274-0.05mg0.05mg£449.00
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Further Information

Additional Names:
Peroxiredoxin-1, Natural killer cell-enhancing factor A, NKEF-A, Proliferation-associated gene protein, PAG, Thioredoxin peroxidase 2, Thioredoxin-dependent peroxide reductase 2, PAGA, PAGB, TDPX2, PRDX1
Application Note:
This recombinant protein can be used for biological assays. For research use only.
Background:
Peroxiredoxin-1(PRDX1) contains 1 thioredoxin domain and belongs to the AhpC/TSA family. PRDX1 constitutively expressed in most human cells and it is induced to higher levels upon serum stimulation in untransformed and transformed cells. PRDX1 is involved in redox regulation of the cell. It reduces peroxides with reducing equivalents provided through the thioredoxin system but not from glutaredoxin and play an important role in eliminating peroxides generated during metabolism. PRDX1 might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H2O2. It reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation. It may contribute to the antiviral activity of CD8(+) T-cells and have a proliferative effect in cancer development or progression.
Buffer:
Supplied as a 0.2 um filtered solution of PBS, 10% glycerol, 0.1mM DTT,pH 6.0. It is not recommended to reconstitute to a concentration less than 100 ug/ml.
Fusion Tag:
N, C-6 His tag
NCBI Gene ID #:
5052
NCBI Official Name:
peroxiredoxin 1
NCBI Official Symbol:
PRDX1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Predicted Molecular Weight:
25.3 kD
Protein Accession #:
Q06830
Protein GI Number:
767920419
Purity:
Greater than 95% as determined by reducing SDS-PAGE.
Endotoxin level less than 0.1 ng/ug (1 IEU/ug) as determined by LAL test.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
E. coli
Swissprot #:
Q06830

Documents