ProSci

Isocitrate Dehydrogenase Recombinant Protein

Product Code:
 
PSI-92-626
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Regulatory Status:
 
RUO
Target Species:
 
Human
Storage:
 
Store at -20˚C, stable for 6 months after receipt.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
 

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PSI-92-626-0.05mg0.05mg£883.00
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Further Information

Additional Names:
Isocitrate Dehydrogenase [NADP] Cytoplasmic, IDH, Cytosolic NADP-Isocitrate Dehydrogenase, IDP, NADP(+)-Specific ICDH, Oxalosuccinate Decarboxylase, IDH1, PICD
Application Note:
This recombinant protein can be used for biological assays. For research use only.
Background:
Isocitrate Dehydrogenase [NADP] Cytoplasmic (IDH1) belongs to the isocitrate and isopropylmalate dehydrogenases family. IDH1 exists as a homodimer, binding one magnesium or manganese ion per subunit. Mutations of IDH1 have been shown to cause metaphyseal chondromatosis with aciduria and are involved in the development of glioma. IDH plays a role in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid.
Buffer:
Supplied as a 0.2 um filtered solution of 50mM Tris, 200mM NaCl, 10% glycerol, pH8.0. It is not recommended to reconstitute to a concentration less than 100 ug/ml.
Fusion Tag:
C-8 His tag
NCBI Gene ID #:
3417
NCBI Official Name:
isocitrate dehydrogenase 1 (NADP+)
NCBI Official Symbol:
IDH1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Predicted Molecular Weight:
48.1 kD
Protein Accession #:
O75874
Purity:
Greater than 94% as determined by reducing SDS-PAGE.
Endotoxin level less than 0.1 ng/ug (1 IEU/ug).
Recombinant Protein Sequence:
Thr32-Gly402
Source:
E. coli
Swissprot #:
O75874

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