ProSci

MGMT Recombinant Protein

Product Code:
 
PSI-92-212
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Regulatory Status:
 
RUO
Target Species:
 
Human
Storage:
 
Store at -20˚C, stable for 6 months after receipt.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
 

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PSI-92-212-0.05mg0.05mg£673.00
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Further Information

Additional Names:
Methylated-DNA--protein-cysteine methyltransferase, 6-O-methylguanine-DNAmethyltransferase, O-6-methylguanine-DNA-alkyltransferase, MGMT
Application Note:
This recombinant protein can be used for biological assays. For research use only.
Background:
MGMT belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. MGMT involved in the cellular defense against the biological effects of O6-methylguanine in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. MGMT catalyzes the chemical reaction: DNA (containing 6-O-methylguanine) and proteinL-cysteine into DNA (without 6-O-methylguanine) and protein S-methyl-L-cysteine.
Buffer:
Supplied as a 0.2 um filtered solution of 20mMTrisHCl,1mM EDTA, pH 8.0 . It is not recommended to reconstitute to a concentration less than 100 ug/ml.
Fusion Tag:
N-6 His tag
NCBI Gene ID #:
4255
NCBI Official Name:
O-6-methylguanine-DNA methyltransferase
NCBI Official Symbol:
MGMT
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Predicted Molecular Weight:
23.8 kD
Protein Accession #:
P16455
Protein GI Number:
530394832
Purity:
Greater than 95% as determined by reducing SDS-PAGE.
Endotoxin level less than 0.1 ng/ug (1 IEU/ug) as determined by LAL test.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
E. coli
Swissprot #:
P16455

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