Selonsertib
| Code | Size | Price |
|---|
| SYN-1231-M100 | 100 mg | Enquire |
Quantity:
| SYN-1231-M001 | 1 mg | £115.00 |
Quantity:
| SYN-1231-M005 | 5 mg | £233.00 |
Quantity:
| SYN-1231-M010 | 10 mg | £350.00 |
Quantity:
| SYN-1231-M050 | 50 mg | £1,053.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
Ambient
Storage:
4°C
Documents
Further Information
Alternate Names/Synonyms:
GS-4997 (free base); 5-(4-Cyclopropyl-1H-imidazol-1-yl)-2-fluoro-N-(6-(4-isopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-yl)-4-methylbenzamide
Appearance:
Solid.
CAS:
1448428-04-3
EClass:
32160000
Form (Short):
liquid
Handling Advice:
Keep cool and dry.
InChi:
InChI=1S/C24H24FN7O/c1-14(2)32-13-27-30-23(32)19-5-4-6-22(28-19)29-24(33)17-10-21(15(3)9-18(17)25)31-11-20(26-12-31)16-7-8-16/h4-6,9-14,16H,7-8H2,1-3H3,(H,28,29,33)
InChiKey:
YIDDLAAKOYYGJG-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 1448428-04-3. Formula: C24H24FN7O. MW: 445.5. Selonsertib, also known as GS-4997, is an orally bioavailable inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with potential anti-inflammatory, antineoplastic and anti-fibrotic activities. GS-4997 targets and binds to the catalytic kinase domain of ASK1 in an ATP-competitive manner. GS-4997 prevents the production of inflammatory cytokines, down-regulates the expression of genes involved in fibrosis, suppresses excessive apoptosis and inhibits cellular proliferation.
Molecular Formula:
C24H24FN7O
Molecular Weight:
445.5
Package Type:
Plastic Vial
Product Description:
Selonsertib, also known as GS-4997, is an orally bioavailable inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with potential anti-inflammatory, antineoplastic and anti-fibrotic activities. GS-4997 targets and binds to the catalytic kinase domain of ASK1 in an ATP-competitive manner. GS-4997 prevents the production of inflammatory cytokines, down-regulates the expression of genes involved in fibrosis, suppresses excessive apoptosis and inhibits cellular proliferation.
Purity:
>95%
Solubility Chemicals:
Soluble in DMSO. Insoluble in water.
Transportation:
Non-hazardous
UNSPSC Category:
Protein Kinase Modulators
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
Design of a phase 2 clinical trial of an ASK1 inhibitor, GS-4997, in patients with diabetic kidney disease: J.H. Lin, et al.; Nephron 129, 29 (2015) | A Quantitative Framework to Evaluate Proarrhythmic Risk in a First-in-Human Study to Support Waiver of a Thorough QT Study: C.H. Nelson, et al.; Clin. Pharmacol. Ther. 98, 630 (2015)
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