PI103
| Code | Size | Price |
|---|
| SYN-1065-M100 | 100 mg | Enquire |
Quantity:
| SYN-1065-M001 | 1 mg | £121.00 |
Quantity:
| SYN-1065-M005 | 5 mg | £180.00 |
Quantity:
| SYN-1065-M010 | 10 mg | £279.00 |
Quantity:
| SYN-1065-M050 | 50 mg | £537.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
PI-103
Appearance:
Solid.
CAS:
371935-74-9
EClass:
32160000
Form (Short):
liquid
InChi:
InChI=1S/C19H16N4O3/c24-13-4-1-3-12(11-13)17-21-15-14-5-2-6-20-19(14)26-16(15)18(22-17)23-7-9-25-10-8-23/h1-6,11,24H,7-10H2
InChiKey:
TUVCWJQQGGETHL-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 371935-74-9. Formula: C19H16N4O3. MW: 348.4. PI-103 is an isoform-selective class I PI3K and mTOR inhibitor. It has activity on p110alpha-delta with IC(50) values of 2nM, 3nM, 3nM, 15nM respectively. It is less potent against mTOR and DNA-PK with IC(50) values of 30nM and 23nM respectively.
Molecular Formula:
C19H16N4O3
Molecular Weight:
348.4
Package Type:
Plastic Vial
Product Description:
PI-103 is an isoform-selective class I PI3K and mTOR inhibitor. It has activity on p110alpha-delta with IC(50) values of 2nM, 3nM, 3nM, 15nM respectively. It is less potent against mTOR and DNA-PK with IC(50) values of 30nM and 23nM respectively.
Purity:
>95%
Solubility Chemicals:
Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol.
Transportation:
Non-hazardous
UNSPSC Category:
Protein Kinase Modulators
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma: Q.W. Fan, et al.; Cancer Cell 9, 341 (2006)
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