IPI-145
| Code | Size | Price |
|---|
| SYN-1175-M100 | 100 mg | Enquire |
Quantity:
| SYN-1175-M001 | 1 mg | £133.00 |
Quantity:
| SYN-1175-M005 | 5 mg | £203.00 |
Quantity:
| SYN-1175-M010 | 10 mg | £332.00 |
Quantity:
| SYN-1175-M050 | 50 mg | £1,099.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
IPI 145
Appearance:
Solid.
CAS:
1201438-56-3
EClass:
32160000
Form (Short):
liquid
InChi:
InChI=1S/C22H17ClN6O/c1-13(28-21-19-20(25-11-24-19)26-12-27-21)17-10-14-6-5-9-16(23)18(14)22(30)29(17)15-7-3-2-4-8-15/h2-13H,1H3,(H2,24,25,26,27,28)/t13-/m0/s1
InChiKey:
SJVQHLPISAIATJ-ZDUSSCGKSA-N
Long Description:
Chemical. CAS: 1201438-56-3. Formula: C22H17ClN6O. MW: 416.9. IPI-145 is a potent, oral inhibitor of Class I phosphoinositide-3-kinase (PI3K)-delta and PI3K-gamma (IC(50) of 243 pM and 50nM), and is clinically active in patients with advanced hematological malignancies.
Molecular Formula:
C22H17ClN6O
Molecular Weight:
416.9
Package Type:
Plastic Vial
Product Description:
IPI-145 is a potent, oral inhibitor of Class I phosphoinositide-3-kinase (PI3K)-delta and PI3K-gamma (IC(50) of 243 pM and 50nM), and is clinically active in patients with advanced hematological malignancies.
Purity:
>95%
Solubility Chemicals:
Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol.
Transportation:
Non-hazardous
UNSPSC Category:
Protein Kinase Modulators
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
PI3K-delta and PI3K-gamma inhibition by IPI-145 abrogates immune responses and suppresses activity in autoimmune and inflammatory disease models: D.G. Winkler, et al.; Chem. Biol. 20, 1364 (2013) | Novel phosphoinositide 3-kinase delta,gamma inhibitor: potent anti-inflammatory effects and joint protection in models of rheumatoid arthritis: D.L. Boyle, et al.; J. Pharmacol. Exp. Ther. 348, 271 (2014) | IPI-145 shows promise in CLL patients: Cancer Discov. 4, 136 (2014)
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