PF-04979064
| Code | Size | Price |
|---|
| SYN-1194-M100 | 100 mg | Enquire |
Quantity:
| SYN-1194-M050 | 50 mg | Enquire |
Quantity:
| SYN-1194-M001 | 1 mg | £238.00 |
Quantity:
| SYN-1194-M005 | 5 mg | £461.00 |
Quantity:
| SYN-1194-M010 | 10 mg | £719.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
4°C
Documents
Further Information
Alternate Names/Synonyms:
PF04979064
Appearance:
Solid.
CAS:
1220699-06-8
EClass:
32160000
Form (Short):
liquid
InChi:
InChI=1S/C24H26N6O3/c1-14-4-5-16(12-25-14)18-6-7-19-21(27-18)22-20(13-26-19)28(3)24(33)30(22)17-8-10-29(11-9-17)23(32)15(2)31/h4-7,12-13,15,17,31H,8-11H2,1-3H3/t15-/m0/s1
InChiKey:
GACQNUHFDBEIQH-HNNXBMFYSA-N
Long Description:
Chemical. CAS: 1220699-06-8. Formula: C24H26N6O3. MW: 446.5. PF-04979064 is a potent and selective PI3K/mTOR dual kinase inhibitor with an IC(50) of 9.1nM for the PI3K family when tested AKT phosphorylation in BT20 cells. In direct kinase assays, PF-04979064 has potent Ki values against PI3Kalpha (Ki= 0.13nM human, 0.299nM mouse) and PI3Kgamma (Ki=0.111nM), and PI3Kdelta (Ki=0.122nM). In contrast, Ki values for non-PI3K kinases such as mTOR were 10X higher at 1.42 nM.
Molecular Formula:
C24H26N6O3
Molecular Weight:
446.5
Package Type:
Plastic Vial
Product Description:
PF-04979064 is a potent and selective PI3K/mTOR dual kinase inhibitor with an IC(50) of 9.1nM for the PI3K family when tested AKT phosphorylation in BT20 cells. In direct kinase assays, PF-04979064 has potent Ki values against PI3Kalpha (Ki= 0.13nM human, 0.299nM mouse) and PI3Kgamma (Ki=0.111nM), and PI3Kdelta (Ki=0.122nM). In contrast, Ki values for non-PI3K kinases such as mTOR were 10X higher at 1.42 nM.
Purity:
>95%
Solubility Chemicals:
Soluble in DMSO.
Transportation:
Non-hazardous
UNSPSC Category:
Protein Kinase Modulators
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 1 year after receipt when stored at +4°C.
References
Discovery of the Highly Potent PI3K/mTOR Dual Inhibitor PF-04979064 through Structure-Based Drug Design: H. Cheng, et al.; ACS Med. Chem. Lett. 4, 91 (2012)
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