Anti-Human CD45RO Monoclonal Antibody, Unconjugated Clone UCHL1

Product Code:

854.333.020

Product Group:

Primary Antibodies

Supplier:

Diaclone

Host Type:

Mouse

Antibody Isotype:

IgG2a

Antibody Clonality:

Monoclonal

Antibody Clone:

UCHL1

Regulatory Status:

RUO

Target Species:

Human

Applications:

Immunohistochemistry (IHC)
Immunoprecipitation (IP)

Storage:

Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label.

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Code	Size	Price

854.333.020

100ug/100ul

£371.00

Quantity:

Prices exclude any Taxes / VAT

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Further Information

Antigen:

CD45RO

Conjugate:

Purified

Format:

Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4

Immunisation:

Human IL-2 dependent T cells

Reactivity:

Human

Research Area:

Non Lineage Markers,CD Markers

Specificity:

The antibody UCHL1 recognizes CD45R0, a 180 kDa low molecular weight isoform of the leukocyte common antigen (LCA). The antigen is expressed on a subset of memory/activated T cells and on cortical thymocytes.

Working Dilution:

Use 10 µl of the suggested working dilution to label 106 cells in 100 µl.

Documents

Further Information

References

Akbar A.N. et al., J Immunol., 1988;140(7):2171-8. Loss of CD45R and gain of UCHL1 reactivity is a feature of primed T cells.. https://www.ncbi.nlm.nih.gov/pubmed/2965180
Beverley P.C. et al., Immunol Suppl.,1988;1:3-5. Phenotypic diversity of the CD45 antigen and its relationship to function.. https://www.ncbi.nlm.nih.gov/pubmed/2968306
Beverley P.C., Immunol Lett., 1987;14(4):263-7. Human T cell subsets.. https://www.ncbi.nlm.nih.gov/pubmed/2953677
Bijian K. et al., Mol Immunol., 2007;44(15):3682-90. Collagen-mediated survival signaling is modulated by CD45 in Jurkat T cells.. https://www.ncbi.nlm.nih.gov/pubmed/17524482
Cosenza-Nashat M.A. et al., Brain Pathol. ,2006;16(4):256-65. CD45 isoform expression in microglia and inflammatory cells in HIV-1 encephalitis.. https://www.ncbi.nlm.nih.gov/pubmed/17107594
Dawes R. et al., J Immunol., 2006;176(6):3417-25. Combinations of CD45 isoforms are crucial for immune function and disease.. https://www.ncbi.nlm.nih.gov/pubmed/16517710
Desharnais P. et al., Apoptosis.,2007 Dec 19. Involvement of CD45 in DNA fragmentation in apoptosis induced by mitochondrial perturbing agents.
Leucocyte Typing IV. Knapp W et al. (Eds.), Oxford University Press (1989).. .
Leucocyte Typing V. Schlossman S. et al. (Eds.), Oxford University Press (1995).. .
Leukocyte Typing III., McMichael A. J. et al (Eds.), Oxford University Press (1987). .
Li F.J. et al., Blood, 2005;105(8):3295-302. A rapid translocation of CD45RO but not CD45RA to lipid rafts in IL-6-induced proliferation in myeloma.. https://www.ncbi.nlm.nih.gov/pubmed/15626731
Merkenschlager M. et al., Eur J Immunol.,1988;18(11):1653-61. Limiting dilution analysis of proliferative responses in human lymphocyte populations defined by the monoclonal antibody UCHL1: implications for differential CD45 expression in T cell memory formation.. https://www.ncbi.nlm.nih.gov/pubmed/2974420
Norton A.J. et al., J Clin Pathol., 1986;39(4):399-405. Monoclonal antibody (UCHL1) that recognises normal and neoplastic T cells in routinely fixed tissues.. https://www.ncbi.nlm.nih.gov/pubmed/2422219
Smith S.H. et al., Immunology, 1986;58(1):63-70. Functional subsets of human helper-inducer cells defined by a new monoclonal antibody, UCHL1.. https://www.ncbi.nlm.nih.gov/pubmed/2423439
Terry L.A. et al., Immunology, 1988;64(2):331-6. The monoclonal antibody, UCHL1, recognizes a 180,000 MW component of the human leucocyte-common antigen, CD45.. https://www.ncbi.nlm.nih.gov/pubmed/2455685