AdipoGen Life Sciences

ID-8

Product Code:
 
AG-CR1-3655
Product Group:
 
Inhibitors and Activators
Regulatory Status:
 
RUO
Shipping:
 
-20°C
Storage:
 
Short Term: +4°C. Long Term: -20°C
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Chemical Structure
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Chemical Structure

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AG-CR1-3655-M0011 mg£35.00
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AG-CR1-3655-M0055 mg£55.00
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AG-CR1-3655-M02525 mg£190.00
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This product comes from: Switzerland.
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Further Information

Alternate Names/Synonyms:
1-(4-Methoxyphenyl)-2-methyl-3-nitro-1H-indol-6-ol
Appearance:
Solid.
CAS:
147591-46-6
EClass:
32160000
Form (Short):
liquid
Handling Advice:
Keep cool and dry.
InChi:
InChI=1S/C16H14N2O4/c1-10-16(18(20)21)14-8-5-12(19)9-15(14)17(10)11-3-6-13(22-2)7-4-11/h3-9,19H,1-2H3
InChiKey:
VVZNWYXIOADGSW-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 147591-46-6. Formula: C16H14N2O4. MW: 298.3. Synthetic. Cell culture supplement that can sustain self-renewal and pluripotency of mouse embryonic stem cells (ESCs) in vitro. At 10µM it stimulates proliferation in serum-free media at a steady rate for more than 30 days. Reversibly maintains the long-term culture of ESCs by sustaining Nanog gene expression through Sox2-Oct3/4 activation and enhances Wnt-mediated hESC survival and proliferation via inhibition of DYRKs (DYRK2 and DYRK4).
MDL:
MFCD00593367
Molecular Formula:
C16H14N2O4
Molecular Weight:
298.3
Package Type:
Plastic Vial
Product Description:
Cell culture supplement that can sustain self-renewal and pluripotency of mouse embryonic stem cells (ESCs) in vitro. At 10µM it stimulates proliferation in serum-free media at a steady rate for more than 30 days. Reversibly maintains the long-term culture of ESCs by sustaining Nanog gene expression through Sox2-Oct3/4 activation and enhances Wnt-mediated hESC survival and proliferation via inhibition of DYRKs (DYRK2 and DYRK4).
Purity:
>98% (1H-NMR)
SMILES:
CC1=C([N+]([O-])=O)C2=CC=C(O)C=C2N1C3=CC=C(OC)C=C3
Solubility Chemicals:
Soluble in DMSO (25mg/ml) and DMF (30mg/ml).
Transportation:
Non-hazardous
UNSPSC Category:
Protein Kinase Modulators
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.

References

Indole derivatives sustain embryonic stem cell self-renewal in long-term culture: T. Miyabayashi, et al.; Biosci. Biotechnol. Biochem. 72, 1242 (2008) | Wnt signaling orchestration with a small molecule DYRK inhibitor provides long-term xeno-free human pluripotent cell expansion: K. Hasegawa, et al.; Stem Cells Transl. Med. 1, 18 (2012)