Antibody Isotype:
Rabbit Ig
Antibody Clonality:
Polyclonal
Application:
Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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This product comes from:
United States.
Typical lead time:
14-21 working days.
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- Further Information
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Further Information
Androgen receptor, Dihydrotestosterone receptor, Nuclear receptor subfamily 3 group C member 4, AR, DHTR, NR3C4
For WB starting dilution is: 1:1000
The androgen receptor gene is more than 90 kb long and
codes for a protein that has 3 major functional domains: the
N-terminal domain, DNA-binding domain, and androgen-binding domain.
The protein functions as a steroid-hormone activated transcription
factor. Upon binding the hormone ligand, the receptor dissociates
from accessory proteins, translocates into the nucleus, dimerizes,
and then stimulates transcription of androgen responsive genes.
This gene contains 2 polymorphic trinucleotide repeat segments that
encode polyglutamine and polyglycine tracts in the N-terminal
transactivation domain of its protein. Expansion of the
polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy
disease). Mutations in this gene are also associated with complete
androgen insensitivity (CAIS). Two alternatively spliced variants
encoding distinct isoforms have been described. [provided by
RefSeq].
- Shu, S.K., et al. J. Biol. Chem. 285(43):33045-33053(2010)
- Nedelsky, N.B., et al. Neuron 67(6):936-952(2010)
- Panda, B., et al. Gynecol. Endocrinol. (2010) In press :
- Schneider, G., et al. AmGeriatr Psychiatry (2010) In press :
Supplied in PBS with 0.09% (W/V) sodium azide.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Predicted species reactivity based on immunogen sequence: Monkey
This AR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 282-309 amino acids from the Central region of human AR.
367
Androgen receptor
AR
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
99 kDa
P10275
113830
This antibody is purified through a protein A column, followed by peptide affinity purification.
Cancer,Cell Cycle,Signal Transduction
P10275
Optimal dilutions for each application to be determined by the researcher.