ABCD2 Antibody

Product Code:

PSI-56-546

Product Group:

Primary Antibodies

Supplier:

ProSci

Host Type:

Rabbit

Antibody Isotype:

Rabbit Ig

Antibody Clonality:

Polyclonal

Regulatory Status:

RUO

Target Species:

Human

Applications:

Fluorescence-activated cell sorting (FACS)
Immunohistochemistry- Paraffin Embedded (IHC-P)
Western Blot (WB)

Storage:

Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

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Code	Size	Price

PSI-56-546-400ul

400ul

£626.00

Quantity:

Prices exclude any Taxes / VAT

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Further Information

Additional Names:

ATP-binding cassette sub-family D member 2, Adrenoleukodystrophy-like 1, Adrenoleukodystrophy-related protein, hALDR, ABCD2, ALD1, ALDL1, ALDR, ALDRP

Application Note:

For WB starting dilution is: 1:1000

For IHC-P starting dilution is: 1:10~50

For FACS starting dilution is: 1:10~50

Background:

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. The function of this peroxisomal membrane protein is unknown; however this protein is speculated to function as a dimerization partner of ABCD1 and/or other peroxisomal ABC transporters. Mutations in this gene have been observed in patients with adrenoleukodystrophy, a severe demyelinating disease. This gene has been identified as a candidate for a modifier gene, accounting for the extreme variation among adrenoleukodystrophy phenotypes. This gene is also a candidate for a complement group of Zellweger syndrome, a genetically heterogeneous disorder of peroxisomal biogenesis.

Background References:

Matsukawa, T., et al. Neurogenetics (2010) In press :
Saito, A., et al. J. Hum. Genet. 54(6):317-323(2009)
Maier, E.M., et al. Biochem. Biophys. Res. Commun. 377(1):176-180(2008)
Lu, Y., et al. J. Lipid Res. 49(12):2582-2589(2008)

Buffer:

Supplied in PBS with 0.09% (W/V) sodium azide.

Concentration:

batch dependent

Conjugate:

Unconjugated

DISCLAIMER:

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

Immunogen:

This ABCD2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 553-582 amino acids from the C-terminal region of human ABCD2.

NCBI Gene ID #:

225

NCBI Official Name:

ATP-binding cassette sub-family D member 2

NCBI Official Symbol:

ABCD2

NCBI Organism:

Homo sapiens

Physical State:

Liquid

PREDICTED MOLECULAR WEIGHT:

83 kDa

Protein Accession #:

Q9UBJ2

Protein GI Number:

12643305

Purification:

This antibody is purified through a protein A column, followed by peptide affinity purification.

Research Area:

Cancer,Obesity,Signal Transduction

Swissprot #:

Q9UBJ2

User NOte:

Optimal dilutions for each application to be determined by the researcher.

ABCD2 Antibody

Further Information

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