ProSci

IMPDH2 Antibody

Product Code:
 
PSI-62-875
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit Ig
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Human
Applications:
  • Fluorescence-activated cell sorting (FACS)
  • Immunohistochemistry- Paraffin Embedded (IHC-P)
  • Western Blot (WB)
Storage:
 
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Western blot analysis of IMPDH2 Antibody in NCI-H460,Hela,MCF7,A2058 cell line lysates(35ug/lane)
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IMPDH2 Antibody IHC analysis in formalin fixed and paraffin embedded human Lung carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining.
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Western blot analysis of IMPDH2 Antibody in NCI-H460,Hela,MCF7,A2058 cell line lysates(35ug/lane)
IMPDH2 Antibody IHC analysis in formalin fixed and paraffin embedded human Lung carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining.

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PSI-62-875-400ul400ul£626.00
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Further Information

Additional Names:
Inosine-5'-monophosphate dehydrogenase 2 {ECO:0000255|HAMAP-Rule:MF_03156}, IMP dehydrogenase 2 {ECO:0000255|HAMAP-Rule:MF_03156}, IMPD 2 {ECO:0000255|HAMAP-Rule:MF_03156}, IMPDH 2 {ECO:0000255|HAMAP-Rule:MF_03156}, 111205 {ECO:0000255|HAMAP-Rule:MF_03156}, IMPDH-II, IMPDH2 {ECO:0000255|HAMAP-Rule:MF_03156}, IMPD2
Application Note:
For WB starting dilution is: 1:1000

For IHC-P starting dilution is: 1:50~100

For FACS starting dilution is: 1:10~50
Background:
IMPDH2 is the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. Its gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation.
Background References:
  • Sombogaard,F., Pharmacogenet. Genomics 19 (8), 626-634 (2009)
  • Mohamed,M.F., Genet. Test. 12 (4), 513-516 (2008)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Bovine, Mouse, Rat, Hamster, Zebrafish
Immunogen:
This IMPDH2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 180-210 amino acids from the Central region of human IMPDH2.
NCBI Gene ID #:
3615
NCBI Official Name:
Inosine-5'-monophosphate dehydrogenase 2 {ECO:0000255|HAMAP-Rule:MF_03156}
NCBI Official Symbol:
IMPDH2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
56 kDa
Protein Accession #:
P12268
Protein GI Number:
124419
Purification:
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Research Area:
Cancer,Obesity,Signal Transduction
Swissprot #:
P12268
User NOte:
Optimal dilutions for each application to be determined by the researcher.