Further Information
Serpin B8, Cytoplasmic antiproteinase 2, CAP-2, CAP2, Peptidase inhibitor 8, PI-8, SERPINB8, PI8
For WB starting dilution is: 1:1000
The superfamily of high molecular weight serine proteinase
inhibitors (serpins) regulate a diverse set of intracellular and
extracellular processes such as complement activation,
fibrinolysis, coagulation, cellular differentiation, tumor
suppression, apoptosis, and cell migration. Serpins are
characterized by well-conserved a tertiary structure that consists
of 3 beta sheets and 8 or 9 alpha helices (Huber and Carrell, 1989
[PubMed 2690952]). A critical portion of the molecule, the reactive
center loop connects beta sheets A and C. Protease inhibitor-8
(PI8; SERPINB8) is a member of the ov-serpin subfamily, which,
relative to the archetypal serpin PI1 (MIM 107400), is
characterized by a high degree of homology to chicken ovalbumin,
lack of N- and C-terminal extensions, absence of a signal peptide,
and a serine rather than an asparagine residue at the penultimate
position (summary by Bartuski et al., 1997 [PubMed
9268635]).
- Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
- de Koning, P.J., et al. Pancreas 38(4):461-467(2009)
- Luke, M.M., et al. Stroke 40(2):363-368(2009)
- Shiffman, D., et al. Arterioscler. Thromb. Vasc. Biol. 28(1):173-179(2008)
Supplied in PBS with 0.09% (W/V) sodium azide.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
This SERPINB8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 274-301 amino acids from the C-terminal region of human SERPINB8.
5271
Serpin B8
SERPINB8
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
43 kDa
P50452
212276474
This antibody is purified through a protein A column, followed by peptide affinity purification.
Cell Cycle
P50452
Optimal dilutions for each application to be determined by the researcher.