Further Information
Neutrophil defensin 3, Defensin, alpha 3, HNP-3, HP-3, HP3, HP 3-56, Neutrophil defensin 2, HNP-2, HP-2, HP2, DEFA3, DEF3
For WB starting dilution is: 1:1000
Defensins are a family of microbicidal and cytotoxic
peptides thought to be involved in host defense. They are abundant
in the granules of neutrophils and also found in the epithelia of
mucosal surfaces such as those of the intestine, respiratory tract,
urinary tract, and vagina. Members of the defensin family are
highly similar in protein sequence and distinguished by a conserved
cysteine motif. The protein encoded by this gene, defensin, alpha
3, is found in the microbicidal granules of neutrophils and likely
plays a role in phagocyte-mediated host defense. Several alpha
defensin genes are clustered on chromosome 8. This gene differs
from defensin, alpha 1 by only one amino acid. This gene and the
gene encoding defensin, alpha 1 are both subject to copy number
variation.
- Han, S., et al. Hum. Immunol. 71(7):727-730(2010)
- Chen, Q., et al. Anesthesiology 112(6):1428-1434(2010)
- Rajaraman, P., et al. Cancer Epidemiol. Biomarkers Prev. 19(5):1356-1361(2010)
- Paslakis, G., et al. Nephron Exp. Nephrol. 115 (4), E96-E100 (2010) :
Supplied in PBS with 0.09% (W/V) sodium azide.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
This DEFA3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 38-65 amino acids from the C-terminal region of human DEFA3.
1668
Neutrophil defensin 3
DEFA3
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
10 kDa
P59666
30316323
This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunology,
P59666
Optimal dilutions for each application to be determined by the researcher.