Further Information
Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1, Glucosaminyl N-deacetylase/N-sulfotransferase 1, NDST-1, N-heparan sulfate sulfotransferase 1, N-HSST 1, [Heparan sulfate]-glucosamine N-sulfotransferase 1, HSNST 1, Heparan sulfate N-deacetylase 1, 3---, Heparan sulfate N-sulfotransferase 1, 282-, NDST1, HSST, HSST1
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:10~50
NDST1 is an essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA dissacharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Plays a role in determining the extent and pattern of sulfation of heparan sulfate. Compared to other NDST enzymes, its presence is absolutely required. Participates in biosynthesis of heparan sulfate that can ultimately serve as L-selectin ligands, thereby playing a role in inflammatory response.
- Yoshida, T., et al. Int. J. Mol. Med. 25(4):649-656(2010)
- Oguri, M., et al. Am. J. Hypertens. 23(1):70-77(2010)
- Duelli, A., et al. J. Immunol. 183(11):7073-7083(2009)
- Zuberi, R.I., et al. J. Immunol. 183(6):3971-3979(2009)
Supplied in PBS with 0.09% (W/V) sodium azide.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Predicted species reactivity based on immunogen sequence: Mouse, Rat
This NDST1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 820-849 amino acids from the C-terminal region of human NDST1.
3340
Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1
NDST1
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
101 kDa
P52848
This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunology,Signal Transduction
P52848
Optimal dilutions for each application to be determined by the researcher.