Antibody Isotype:
Rabbit Ig
Antibody Clonality:
Polyclonal
Applications:- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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This product comes from:
United States.
Typical lead time:
14-21 working days.
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- Further Information
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Further Information
Tyrosine-protein kinase ZAP-70, 70 kDa zeta-chain associated protein, Syk-related tyrosine kinase, ZAP70, SRK
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:10~50
This gene encodes an enzyme belonging to the protein
tyrosine kinase family, and it plays a role in T-cell development
and lymphocyte activation. This enzyme, which is phosphorylated on
tyrosine residues upon T-cell antigen receptor (TCR) stimulation,
functions in the initial step of TCR-mediated signal transduction
in combination with the Src family kinases, Lck and Fyn. This
enzyme is also essential for thymocyte development. Mutations in
this gene cause selective T-cell defect, a severe combined
immunodeficiency disease characterized by a selective absence of
CD8-positive T-cells. Two transcript variants that encode different
isoforms have been found for this gene.
- Zanotti, R., et al. Am. J. Hematol. 85(7):494-498(2010)
- Lin, Y.P., et al. Mol. Immunol. 47 (11-12), 2022-2029 (2010) :
- Liu, H., et al. Proc. Natl. Acad. Sci. U.S.A. 107(22):10166-10171(2010)
- Kotaskova, J., et al.Mol Diagn 12(3):328-334(2010)
Supplied in PBS with 0.09% (W/V) sodium azide.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Predicted species reactivity based on immunogen sequence: Mouse
This ZAP70 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 103-130 amino acids from the N-terminal region of human ZAP70.
7535
Tyrosine-protein kinase ZAP-70
ZAP70
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
70 kDa
P43403
1177044
This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunology,Signal Transduction
P43403
Optimal dilutions for each application to be determined by the researcher.