Further Information
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha, GMP-PDE alpha, PDE V-B1, PDE6A, PDEA
For WB starting dilution is: 1:1000
This gene encodes the cyclic-GMP (cGMP)-specific
phosphodiesterase 6A alpha subunit, expressed in cells of the
retinal rod outer segment. The phosphodiesterase 6 holoenzyme is a
heterotrimer composed of an alpha, beta, and two gamma subunits.
cGMP is an important regulator of rod cell membrane current, and
its dynamic concentration is established by phosphodiesterase 6A
cGMP hydrolysis and guanylate cyclase cGMP synthesis. The protein
is a subunit of a key phototransduction enzyme and participates in
processes of transmission and amplification of the visual signal.
Mutations in this gene have been identified as one cause of
autosomal recessive retinitis pigmentosa.
- Clark, G.R., et al. Ophthalmology 117(11):2169-2177(2010)
- Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
- Perlis, R.H., et al. Biol. Psychiatry 67(11):1110-1113(2010)
- Bazhin, A.V., et al. Cell. Mol. Life Sci. 67(5):817-828(2010)
Supplied in PBS with 0.09% (W/V) sodium azide.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Predicted species reactivity based on immunogen sequence: Bovine, Mouse
This PDE6A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 308-336 amino acids from the Central region of human PDE6A.
5145
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha
PDE6A
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
100 kDa
P16499
215274230
This antibody is purified through a protein A column, followed by peptide affinity purification.
Neuroscience,Signal Transduction
P16499
Optimal dilutions for each application to be determined by the researcher.