ProSci

ARHGEF6 Antibody

Product Code:
 
PSI-58-685
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit Ig
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Western Blot (WB)
Storage:
 
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Western blot analysis in K562 cell line lysates (35ug/lane).
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Western blot analysis in K562 cell line lysates (35ug/lane).

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PSI-58-685-400ul400ul£626.00
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Further Information

Additional Names:
Rho guanine nucleotide exchange factor 6, Alpha-Pix, COOL-2, PAK-interacting exchange factor alpha, Rac/Cdc42 guanine nucleotide exchange factor 6, ARHGEF6, COOL2, KIAA0006, PIXA
Application Note:
For WB starting dilution is: 1:1000
Background:
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It may form a complex with G proteins and stimulate Rho-dependent signals. This protein is activated by PI3-kinase. Mutations in this gene can cause X-chromosomal non-specific mental retardation. [provided by RefSeq].
Background References:
  • Maiti, A.K. Pharmacogenomics J. 10(2):94-104(2010)
  • Eriguchi, M., et al. J. Neurol. Sci. 290 (1-2), 80-85 (2010) :
  • Takefuji, M., et al. J. Hum. Genet. 55(1):42-49(2010)
  • Lim, J.W., et al. Scand. J. Gastroenterol. 44(10):1166-1172(2009)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This ARHGEF6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 614-641 amino acids from the C-terminal region of human ARHGEF6.
NCBI Gene ID #:
9459
NCBI Official Name:
Rho guanine nucleotide exchange factor 6
NCBI Official Symbol:
ARHGEF6
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
87 kDa
Protein Accession #:
Q15052
Protein GI Number:
17371603
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Signal Transduction
Swissprot #:
Q15052
User NOte:
Optimal dilutions for each application to be determined by the researcher.