Further Information
NEDD8-activating enzyme E1 catalytic subunit, 632-, NEDD8-activating enzyme E1C, Ubiquitin-activating enzyme E1C, Ubiquitin-like modifier-activating enzyme 3, Ubiquitin-activating enzyme 3, UBA3, UBE1C
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:50~100
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme associates with AppBp1, an amyloid beta precursor protein binding protein, to form a heterodimer, and then the enzyme complex activates NEDD8, a ubiquitin-like protein, which regulates cell division, signaling and embryogenesis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
- Bohnsack, R.N., et al., J. Biol. Chem. 278(29):26823-26830 (2003).
- Walden, H., et al., Nature 422(6929):330-334 (2003).
- Gong, L., et al., J. Biol. Chem. 274(17):12036-12042 (1999).
- Gubin, A.N., et al., Genomics 59(2):168-177 (1999).
Supplied in PBS with 0.09% (W/V) sodium azide.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Predicted species reactivity based on immunogen sequence: Zebrafish, Rat
This UBE1C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 415-445 amino acids from the C-terminal region of human UBE1C.
9039
NEDD8-activating enzyme E1 catalytic subunit
UBA3
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
52 kDa
Q8TBC4
83305811
This antibody is purified through a protein A column, followed by peptide affinity purification.
Cell Cycle
Q8TBC4
Optimal dilutions for each application to be determined by the researcher.