ProSci

NUP50 Antibody

Product Code:
 
PSI-60-337
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit Ig
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Mouse
Application:
 
Western Blot (WB)
Storage:
 
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
1 / 2
Western blot analysis of NUP50 using rabbit polyclonal NUP50 Antibody using 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the NUP50 gene (Lane 2).
2 / 2
Western blot analysis of anti-NUP50 Pab in mouse brain tissue lysate.
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Western blot analysis of NUP50 using rabbit polyclonal NUP50 Antibody using 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the NUP50 gene (Lane 2).
Western blot analysis of anti-NUP50 Pab in mouse brain tissue lysate.

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PSI-60-337-400ul400ul£626.00
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Further Information

Additional Names:
Nuclear pore complex protein Nup50, 50 kDa nucleoporin, Nuclear pore-associated protein 60 kDa-like, Nucleoporin Nup50, NUP50, NPAP60L
Application Note:
For WB starting dilution is: 1:1000
Background:
The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. NUP50 is a member of the FG-repeat containing nucleoporins that functions as a soluble cofactor in importin-alpha:beta-mediated nuclear protein import. NUP50 may serve as a binding site on the nuclear side of the pore complex for export receptor-cargo complexes. It interacts with multiple transport receptor proteins including p27Kip1. This interaction is required for correct intracellular transport and degradation of p27Kip1.
Background References:
  • Lindsay, M.E., et al., Cell 110(3):349-360 (2002).
  • Swaminathan, S., et al., Dev. Cell 3(3):304-306 (2002).
  • Smitherman, M., et al., Mol. Cell. Biol. 20(15):5631-5642 (2000).
  • Guan, T., et al., Mol. Cell. Biol. 20(15):5619-5630 (2000).
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Rat
Immunogen:
This NUP50 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 432-461 amino acids from the C-terminal region of human NUP50.
NCBI Gene ID #:
10762
NCBI Official Name:
Nuclear pore complex protein Nup50
NCBI Official Symbol:
NUP50
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
50 kDa
Protein Accession #:
Q9UKX7
Protein GI Number:
20455193
Purification:
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Research Area:
Cell Cycle,Signal Transduction
Swissprot #:
Q9UKX7
User NOte:
Optimal dilutions for each application to be determined by the researcher.