ProSci

PRL1 Antibody

Product Code:
 
PSI-63-471
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit Ig
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Mouse
Application:
 
Western Blot (WB)
Storage:
 
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Western blot analysis of PRL1 in mouse spleen tissue lysates (35ug/lane)
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Western blot analysis of PRL1 in mouse spleen tissue lysates (35ug/lane)

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PSI-63-471-400ul400ul£626.00
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Further Information

Additional Names:
Protein tyrosine phosphatase type IVA 1, PTP(CAAXI), Protein-tyrosine phosphatase 4a1, Protein-tyrosine phosphatase of regenerating liver 1, PRL-1, PTP4A1, PRL1, PTPCAAX1
Application Note:
For WB starting dilution is: 1:1000
Background:
The protein encoded by this gene belongs to a small class of prenylated protein tyrosine phosphatases (PTPs), which contains a PTP domain and a characteristic C-terminal prenylation motif. PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. This tyrosine phosphatase is a nuclear protein, but may primarily associate with plasma membrane. The surface membrane association of this protein depends on its C-terminal prenylation. Overexpression of this gene in mammalian cells conferred a transformed phenotype, which implicated its role in the tumorigenesis. Studies in rat suggested that this gene may be an immediate-early gene in mitogen-stimulated cells.PRL phosphatases increase cell proliferation by stimulating progression from G1 into S phase. PRL-1 function is regulated in a cell cycle-dependent manner and implicate PRL-1 in regulating progression through mitosis, possibly by modulating spindle dynamics.
Background References:
  • Jeong,D.G., et al. J. Mol. Biol. 345 (2), 401-413 (2005)
  • Werner,S.R., et al. Cancer Lett. 202 (2), 201-211 (2003)
  • Wang,J., et al. J. Biol. Chem. 277 (48), 46659-46668 (2002)
  • Nicolas,G., et al. Mol. Cell. Biol. 22 (10), 3527-3536 (2002)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This PRL1 antibody is generated from rabbits immunized with a recombinant protein encoding full length of human PRL1.
NCBI Gene ID #:
7803
NCBI Official Name:
Protein tyrosine phosphatase type IVA 1
NCBI Official Symbol:
PTP4A1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
20 kDa
Protein Accession #:
Q93096
Protein GI Number:
68566217
Purification:
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Research Area:
Signal Transduction
Swissprot #:
Q93096
User NOte:
Optimal dilutions for each application to be determined by the researcher.