ProSci

SH3BP2 Antibody

Product Code:
 
PSI-58-642
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit Ig
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Mouse
Application:
 
Western Blot (WB)
Storage:
 
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Western blot analysis in mouse spleen tissue lysates (35ug/lane).
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Western blot analysis in mouse spleen tissue lysates (35ug/lane).

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PSI-58-642-400ul400ul£626.00
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Further Information

Additional Names:
SH3 domain-binding protein 2, 3BP-2, SH3BP2, 3BP2
Application Note:
For WB starting dilution is: 1:1000
Background:
The protein encoded by this gene has an N-terminal pleckstrin homology (PH) domain, an SH3-binding proline-rich region, and a C-terminal SH2 domain. The protein binds to the SH3 domains of several proteins including the ABL1 and SYK protein tyrosine kinases , and functions as a cytoplasmic adaptor protein to positively regulate transcriptional activity in T, natural killer (NK), and basophilic cells. Mutations in this gene result in cherubism. Multiple transcript variants encoding different isoforms have been found for this gene.
Background References:
  • Lietman, S.A., et al. J. Orthop. Res. 28(11):1425-1430(2010)
  • Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
  • Davila, S., et al. Genes Immun. 11(3):232-238(2010)
  • Amaral, F.R., et al. J. Oral Pathol. Med. 39(3):269-274(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This SH3BP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 151-180 amino acids from the Central region of human SH3BP2.
NCBI Gene ID #:
6452
NCBI Official Name:
SH3 domain-binding protein 2
NCBI Official Symbol:
SH3BP2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
62 kDa
Protein Accession #:
P78314
Protein GI Number:
3023207
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Signal Transduction
Swissprot #:
P78314
User NOte:
Optimal dilutions for each application to be determined by the researcher.