Antibody Isotype:
Rabbit IgG
Antibody Clonality:
Polyclonal
Applications:- Fluorescence-activated cell sorting (FACS)
- Immunofluorescence (IF)
- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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This product comes from:
United States.
Typical lead time:
14-21 working days.
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Further Information
Leucine-rich repeat-containing G-protein coupled receptor 5, G-protein coupled receptor 49, G-protein coupled receptor 67, G-protein coupled receptor HG38, LGR5, GPR49, GPR67
For FACS starting dilution is: 1:25
For IHC-P starting dilution is: 1:25
For WB starting dilution is: 1:2000
LGR5/GPR49 is an orphan receptor. It may be an important receptor for signals controlling growth and differentiation of specific embryonic tissues. Stem cell marker of the intestinal epithelium and the hair follicle. Target gene of Wnt signaling. Expressed in skeletal muscle, placenta, spinal cord, and various region
of brain. Expressed at the base of crypts in colonic and small mucosa
stem cells. In premalignant cancer expression is not restricted to the
cript base. Overexpressed in cancers of the ovary, colon and liver.
- References for protein:
- Barker,N., Nature 449 (7165),1003-1007 (2007)
- Hsu,S.Y., Mol. Endocrinol. 14 (8), 1257-1271 (2000) .
- Yamamoto Y.Sakamoto M., Fujii G., Tsuiji H.Kenetaka K., Asaka M., Hirohashi S. Overexpression of orphan G-protein-coupled receptor, Gpr49, in human hepatocellular carcinomas with beta-catenin mutations. Hepatology 37:528-533(2003).
Supplied in PBS with 0.09% (W/V) sodium azide.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
This LGR5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 689-719 amino acids from human LGR5.
8549
Leucine-rich repeat-containing G-protein coupled receptor 5
LGR5
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
100 kDa
O75473
This antibody is purified through a protein A column, followed by peptide affinity purification.
Cancer,Signal Transduction,Growth Factor
O75473
Optimal dilutions for each application to be determined by the researcher.