ProSci

UBR1 Antibody

Product Code:
 
PSI-60-918
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit Ig
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Mouse
Application:
 
Western Blot (WB)
Storage:
 
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Western blot analysis in mouse liver tissue lysates (35ug/lane).
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Western blot analysis in mouse liver tissue lysates (35ug/lane).

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PSI-60-918-400ul400ul£626.00
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Further Information

Additional Names:
E3 ubiquitin-protein ligase UBR1, 632-, N-recognin-1, Ubiquitin-protein ligase E3-alpha-1, Ubiquitin-protein ligase E3-alpha-I, UBR1
Application Note:
For WB starting dilution is: 1:1000
Background:
The N-end rule pathway is one proteolytic pathway of the ubiquitin system. The recognition component of this pathway, encoded by this gene, binds to a destabilizing N-terminal residue of a substrate protein and participates in the formation of a substrate-linked multiubiquitin chain. This leads to the eventual degradation of the substrate protein. The protein described in this record has a RING-type zinc finger and a UBR-type zinc finger. Mutations in this gene have been associated with Johanson-Blizzard syndrome.
Background References:
  • Elting, M., et al. Am. J. Med. Genet.146A (23), 3058-3061 (2008) :
  • Alkhouri, N., et al. World J. Gastroenterol. 14(44):6863-6866(2008)
  • Yamaguchi, Y., et al. BMC Med. Genet. 9, 22 (2008) :
  • Schmidt, R.L., et al. Cancer Res. 67(24):11798-11810(2007)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This UBR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 245-274 amino acids from the N-terminal region of human UBR1.
NCBI Gene ID #:
197131
NCBI Official Name:
E3 ubiquitin-protein ligase UBR1
NCBI Official Symbol:
UBR1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
200 kDa
Protein Accession #:
Q8IWV7
Protein GI Number:
73622071
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cell Cycle
Swissprot #:
Q8IWV7
User NOte:
Optimal dilutions for each application to be determined by the researcher.