ProSci

Mouse Tlk1 Antibody

Product Code:
 
PSI-59-114
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit Ig
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Mouse
Application:
 
Western Blot (WB)
Storage:
 
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Western blot analysis in mouse Neuro-2a cell line lysates (35ug/lane).

Western blot analysis in mouse Neuro-2a cell line lysates (35ug/lane).

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PSI-59-114-400ul400ul£626.00
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Further Information

Additional Names:
Serine/threonine-protein kinase tousled-like 1, Tousled-like kinase 1, Tlk1
Application Note:
For WB starting dilution is: 1:1000
Background:
Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly (By similarity). Isoform 3 protects the cells from the ionizing radiation by faciliting the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10' (By similarity).
Background References:
  • Canfield, C., et al. BMC Mol. Biol. 10, 110 (2009) :
  • Taniwaki, T., et al. Dev. Growth Differ. 47(3):163-172(2005)
  • Sunavala-Dossabhoy, G., et al. BMC Mol. Biol. 6, 19 (2005) :
  • Cobellis, G., et al. Nucleic Acids Res. 33 (4), E44 (2005) :
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Human
Immunogen:
This Mouse Tlk1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 701-728 amino acids from the C-terminal region of mouse Tlk1.
NCBI Gene ID #:
228012
NCBI Official Name:
Serine/threonine-protein kinase tousled-like 1
NCBI Official Symbol:
Tlk1
NCBI Organism:
Mus musculus
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
87 kDa
Protein Accession #:
Q8C0V0
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Signal Transduction
Swissprot #:
Q8C0V0
User NOte:
Optimal dilutions for each application to be determined by the researcher.