ProSci

TBCC Antibody

Product Code:
 
PSI-57-065
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit Ig
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Mouse
Application:
 
Western Blot (WB)
Storage:
 
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Western blot analysis in mouse spleen tissue lysates (35ug/lane).This demonstdetected the TBCC protein (arrow).
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Western blot analysis in mouse spleen tissue lysates (35ug/lane).This demonstdetected the TBCC protein (arrow).

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PSI-57-065-400ul400ul£626.00
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Further Information

Additional Names:
Tubulin-specific chaperone C, Tubulin-folding cofactor C, CFC, TBCC
Application Note:
For WB starting dilution is: 1:1000
Background:
Cofactor C is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state.
Background References:
  • Hage-Sleiman, R., et al. BMC Cancer 10, 135 (2010) :
  • Nature 447(7145):661-678(2007)
  • Mungall, A.J., et al. Nature 425(6960):805-811(2003)
  • Bartolini, F., et al. J. Biol. Chem. 277(17):14629-14634(2002)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This TBCC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 20-49 amino acids from the N-terminal region of human TBCC.
NCBI Gene ID #:
6903
NCBI Official Name:
Tubulin-specific chaperone C
NCBI Official Symbol:
TBCC
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
39 kDa
Protein Accession #:
Q15814
Protein GI Number:
313104020
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Signal Transduction
Swissprot #:
Q15814
User NOte:
Optimal dilutions for each application to be determined by the researcher.