ProSci

TIGIT Recombinant Protein

Product Code:
 
PSI-96-799
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Regulatory Status:
 
RUO
Target Species:
  • Cynomolgus Monkey
  • Rhesus Macaque
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Western Blot (WB)
Storage:
 
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
 

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PSI-96-799-0.05mg0.05mg£729.00
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Further Information

Additional Names:
TIGIT,VSIG9,VSTM3
Application Note:
This recombinant protein can be used for E, WB. For research use only.
Background:
T-cell immunoreceptor with Ig and ITIM domains (TIGIT) is also known as V-set and immunoglobulin domain-containing protein 9 (VSIG9), V-set and transmembrane domain-containing protein 3 (VSTM3),which belongs to single-pass type I membrane protein containing an immunoglobulin variable domain, a transmembrane domain and an immunoreceptor tyrosine-based inhibitory motif (ITIM). TIGIT is expressed at low levels on peripheral memory and regulatory CD4+ T-cells and NK cells and is up-regulated following activation of these cells (at protein level). TIGIT binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells.
Background References:
  • Yu X., et al., 2009, Nat. Immunol. 10:48-57.
  • Stengel K.F., et al., 2012, Proc. Natl. Acad. Sci. U.S.A. 109:5399-5404.
  • Lozano E., et al., 2012, J. Immunol. 188:3869-3875.
Biological Activity:
Measured by its binding ability in a functional ELISA. Immobilized Human CD155, His Tag at 10 ug/mL (100 uL/well) can bind Cynomolgus / Rhesus macaque TIGIT, Fc Tag with a linear range of 2.22-20 ug/mL.
Buffer:
50 mM Tris, 100 mM Glycine, pH7.5
Fusion Tag:
Fc Tag
NCBI Official Symbol:
TIGIT
NCBI Organism:
Macaca fascicularis?
Physical State:
Lyophilized
Predicted Molecular Weight:
40 kDa
Protein Accession #:
G7NXM4
Purity:
>95% as determined by SDS-PAGE.

Endotoxin level is less than 1.0 EU per ug by the LAL method.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
HEK293 cells
Swissprot #:
G7NXM4

Documents