ProSci

PCSK9 Recombinant Protein

Product Code:
 
PSI-96-818
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Regulatory Status:
 
RUO
Target Species:
 
Hamster
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Western Blot (WB)
Storage:
 
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
 

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PSI-96-818-0.05mg0.05mg£626.00
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Further Information

Additional Names:
PCSK9,FH3,HCHOLA3,LDLCQ1,NARC1,PC9
Application Note:
This recombinant protein can be used for E, WB. For research use only.
Background:
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is also known as NARC1 (neural apoptosis regulated convertase), is a newly identified subtilase belonging to the peptidase S8 subfamily. Mouse PCSK9 is synthesized as a soluble zymogen, and undergoes autocatalytic intramolecular processing in the endoplasmic reticulum, resulting in the cleavage of its propeptide that remains associated with the secreted active enzyme with a broad alkaline pH optimum. This protein plays a major regulatory role in cholesterol homeostasis. PCSK9 binds to the epidermal growth factor-like repeat A (EGF-A) domain of the low-density lipoprotein receptor (LDLR), inducing LDLR degradation. PCSK9 may also have a role in the differentiation of cortical neurons. Mutations in this gene have been associated with a rare form of autosomal dominant familial hypercholesterolemia (HCHOLA3).
Background References:
  • Seidah NG, et al., Proc. Natl. Acad. Sci. U.S.A. 100 (3): 928?33.
  • Abifadel, M. et al., 2003, Nat. Genet. 34: 154-156.
  • Dubuc G. et al., 2004, Arterioscler. Thromb. Vasc. Biol. 24 (8): 1454?9.
Biological Activity:
Measured by its binding ability in a functional ELISA. Immobilized Human LDL R (High Purity) Protein, Strep Tag at 5 ug/mL (100 uL/well) can bind Hamster PCSK9 Protein, His Tag with a linear range of 6-50 ng/mL.
Buffer:
PBS, pH7.4
Fusion Tag:
His Tag
NCBI Official Symbol:
PCSK9
NCBI Organism:
Cricetulus griseus
Physical State:
Lyophilized
Predicted Molecular Weight:
73 kDa
Protein Accession #:
G3GTK5
Purity:
>95% as determined by SDS-PAGE.

Endotoxin level is less than 1.0 EU per ug by the LAL method.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
HEK293 cells
Swissprot #:
G3GTK5

Documents