ProSci

LRRC32 Recombinant Protein

Product Code:
 
PSI-96-921
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Regulatory Status:
 
RUO
Target Species:
 
Human
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Western Blot (WB)
Storage:
 
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
 

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PSI-96-921-0.1mg0.1mg£801.00
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Further Information

Additional Names:
GARP,Garpin,D11S833E
Application Note:
This recombinant protein can be used for E, WB. For research use only.
Background:
Leucine-rich repeat protein 32 (LRRC32), also known as GARP (glycoprotein A repetitions predominant). LRRC32 expression promotes the acquisition of a Treg phenotype including reduced cellular proliferation, reduced cytokine secretion, and the capacity to suppress the proliferation of na?ve T cells. LRRC32 binds directly to the TGF-beta latency associated peptide (LAP) and tethers latent TGF-beta on the surface of activated Treg cells. The presentation of TGF-beta on Tregs contributes to their ability to suppress na?ve T cell proliferation.
Background References:
  • Battaglia, M., et al., 2009, Eur. J. Immunol. 39(12): 3296-3300.
  • Wang, R. et al. 2008, PloS ONE 3(7): e2705.
  • Probst-Kepper, M. et al. 2009, J. Cell. Mol. Med. 13(9B): 3343-3357.
Biological Activity:
Measured by its binding ability in a functional ELISA. Immobilized Latent TGFB1, N-His at 5 ug/mL (100 uL/well) can bind Human LRRC32, Fc Tag with a linear range of 0.039-2.5 ug/mL.
Buffer:
Tris?with?Glycine,?Arginine?and?NaCl,?pH7.5
Fusion Tag:
Fc Tag
NCBI Gene ID #:
2615
NCBI Official Name:
LRRC32 protein
NCBI Official Symbol:
LRRC32
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
92.6 kDa
Protein Accession #:
Q14392-1
Purity:
>95% as determined by SDS-PAGE.

Endotoxin level is less than 1.0 EU per ug by the LAL method.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
HEK293 cells
Swissprot #:
Q14392-1

Documents