ProSci

IGFBP-4 Recombinant Protein

Product Code:
 
PSI-96-890
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Regulatory Status:
 
RUO
Target Species:
 
Human
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Western Blot (WB)
Storage:
 
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
 

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PSI-96-890-0.05mg0.05mg£657.00
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Further Information

Additional Names:
IGFBP4,IBP-4
Application Note:
This recombinant protein can be used for E, WB. For research use only.
Background:
Insulin-like growth factor-binding protein 4 (IGFBP-4) is also known as IGF-binding protein 4, which contains an IGFBP domain and a thyroglobulin type-I domain. IGFBP-4 binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma in both glycosylated and non-glycosylated forms. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. IGFBP-4 is a unique protein and it consistently inhibits several cancer cells in vivo and in vitro. Its inhibitory action has been shown in vivo in prostate and colon. IGFBP-4 is secreted by all colon cancer cells.
Background References:
  • Tagliabracci V.S., et al., 2015, Cell 161:1619-1632.
  • Culouscou J.M., et al.,1991, Cancer Res. 51:2813-2819.
Biological Activity:
Measured by its binding ability in a functional ELISA. Immobilized Human IGFBP-4, His Tag at 2 ug/mL (100 ul/well),can bind Human IGF-I, Fc Tag with a linear range of 4-30 ng/mL.
Buffer:
PBS, pH7.4
Fusion Tag:
His Tag
NCBI Gene ID #:
3487
NCBI Official Name:
Insulin-like growth factor binding protein 4
NCBI Official Symbol:
IGFBP-4
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
27.9 kDa
Protein Accession #:
AAH16041
Purity:
>95% as determined by SDS-PAGE.

Endotoxin level is less than 1.0 EU per ug by the LAL method.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
HEK293 cells
Swissprot #:
NP_001543.2

Documents